Harald Ott, MD
Founder and CEO
Associate Professor in Surgery
I am a Thoracic Surgeon at the Massachusetts General Brigham in Boston, Associate Professor of Surgery at Harvard Medical School, founding director of the Center for Organ Engineering at MGH, and founder and CEO of IVIVA Medical. Inspired by the need to restore function in patients suffering from organ failure, I began to work on cell therapy and organ engineering over 20 years ago. I had the privilege to receive mentorship from and work with some of the smartest engineers and biologists from all over the world, and mentor well over 100 students and research fellows in both academia and industry myself. I am grateful to see our field mature, and for the opportunity to work with IVIVA’s highly innovative team on developing cures for chronic diseases.
Brock Reeve, MBA
Director, Executive Advisor
CEO, Eos BioInnovation
I was IVIVA’s initial CEO and continue on the Board and am an active advisor to Harald and his team. I am now leading Eos BioInnovation, an investment company focused on incubating and launching companies in the regenerative medicine field. Prior to IVIVA and Eos, I was the Executive Director of the Harvard Stem Cell Institute, a research center that grew to over 370 faculty spanning the schools of Harvard University and its affiliated hospitals. My work at HSCI over the years showed me that despite the exciting advances in cell and gene therapies, we still didn’t have good solutions for organ scale tissue repair. Knowing Harald’s scientific and clinical expertise made me want to join him to help build IVIVA, where we have a practical multidisciplinary approach to create functional, biomimetic, organ scale implants that will solve huge unmet medical needs. Our goal is to help patients by preventing the need for dialysis or waiting for a donor transplant.
Michael Hill, PhD, MBA
Former VP Science & Technology, Medtronic
I am a global-minded healthcare senior executive demonstrating repeat innovation execution from discovery to commercialization and creating intersections to share knowledge to accelerate the cycle of innovation. I believe that regenerative tissue engineering is one of the greatest opportunities to impact patients’ health in the near future; and IVIVA is meeting this challenge by successfully driving tissue engineering platforms from laboratory to commercialization to significantly improve care in patients with end stage renal disease, diabetes and other major chronic conditions.
Charles Klassen, MS
VP of Engineering
I am a bioengineer with a passion for developing novel approaches to tissue engineered scaffolds and culture systems. Following my undergraduate studies in physics at Colby College I became interested in biomedical engineering and the growing subfield of tissue engineered organs. This led me to pursue a master’s degree from Johns Hopkins University in biomedical engineering, during which I was exposed to decellularized tissue scaffolds and perfusion culture, culminating in a project investigating various approaches to recellularize rodent whole liver scaffolds. Since then I have been working at IVIVA with the goal of translating bioartificial organ technology into therapies for end stage renal disease. The promise of organ engineering is a future where organ failure is not a death sentence and donor organ shortage is a solved problem, and working everyday with a team dedicated to these goals is truly inspiring.
Daniel T. Bowers, MS, PhD
I am a scientist and engineer with an interest in improving human health. Following my undergraduate degree in Biomedical Engineering at The Pennsylvania State University I worked at a medical device company and a startup prior to beginning graduate school. At University of Virginia I investigated local drug delivery from oxygen sensitive nanofiber membranes to create an immunomodulated and vascularized environment for the transplantation of pancreatic islets to treat Type 1 Diabetes. I then transitioned to studying intracellular signaling and phenotypic cell migration on electrospun nanofiber substrates, focusing on isolating the effect of fibril curvature at the Pennsylvania State University. As a Hartwell Postdoctoral Fellow at Cornell University and now a Scientist at IVIVA Medical, I am continuing the search for a bioengineered vascularized destination for insulin producing cells. I am excited to be leading IVIVA’s teamwork driven effort to create immediately blood perfusable insulin producing grafts designed at human scale for high cell survival with our platform technology.
Thomas Gallegos, PhD
Cell Biology Lead
During my training I became aware of the scale of unmet donor organ needs and the potential health impact of engineered functional tissue replacements, and also of the potential of integrating the independent and disparate tissue engineering and cell biology research groups who’s goal was to advance the field of tissue engineering. I joined IVIVA to be part of a team of engineers and biologists whose entire energy is focused on the present and singular goal of producing human-scale engineered tissues. Before joining IVIVA, I did my bachelor’s studies in general biology at New Mexico State University, researching avian thermoregulatory physiology as a model of surgical temperature management. As a graduate student at the University of California at San Diego I focused on developmental biology and morphogenesis of the kidney, and later did post-doctoral research at the Salk Institute for Biological Studies and subsequently the Massachusetts General Hospital and Harvard Medical School in human and animal stem cell and renal regeneration studies.
Aneta Przepiorski, PhD
Stem Cell Biologist
I studied kidney stem cell and developmental biology at the University of Auckland, New Zealand. During my Ph.D. I gained experience working with human induced pluripotent stem cells (iPSCs) and developed one of the currently widely used kidney organoid protocols. I am passionate about new technologies involving iPSCs and I joined IVIVA to help utilize iPSC-differentiated cells as an alternative source for our scaffolds. I am excited to integrate these techniques into our everyday workflows.
Graham Marsh, PhD
I earned my PhD in Biomedical Engineering from the University of Rochester. There, I focused on building microfluidic models of human vasculature to study biophysical interactions of blood with the endothelium. After earning my degree, I spent 6 years working in the pharmacutical industry building microphysiological models for drug discovery. I joined Iviva for the opportunity to translate these complex in vitro models out of the lab and into something larger that could provide functional benefit to a patient.
Mohsen Sarikhani, PhD
I earned my PhD from Indian Institute of Science where I explored the signaling pathways regulating cardiac hypertrophy and insulin resistance. To mature my understanding of how signaling pathways can help us to train cells and give them function, I did a postdoc in Harvard Stem Cell and regenerative biology department where I worked on stem cell -based therapies applied to the treatment of heart disease. To translate my knowledge into a more powerful tool that can improve the quality of human life I joined IVIVA’s team where I develop novel approaches to create the necessary cellular building blocks to ultimately save people’s lives.
Susan Nelson, BS
Cell Manufacturing Lead; Research Associate
I have been a Research Associate at IVIVA for 3 years. I have a Bachelors of Science in bioengineering from Endicott College and worked at a immuno-oncology start-up prior to joining the IVIVA team where I run primary and iPSC derived cell expansion and banking. What I find most exciting about IVIVA is how multidisciplinary the team is, which allows me to work on numerous aspects of tissue engineering.
Daniel Cheng, PhD
Research Scaffold Lead
I completed my PhD in Biomedical engineering at Boston University where I used 3D printing approaches to create vascularized tissues, one of the central goals in the field of regenerative medicine. I joined IVIVA with the goal of developing human-scale perfusable tissues that can meet a real clinical need.
Andrew Ford, PhD
Clinical Scaffold Lead
As a PhD candidate at Virginia Tech, my chemical engineering degree took a biomedical turn where I primarily focused on tissue engineering. My research involved investigating the interplay between cell-extracellular matrix interactions and inflammation in a variety of tissues. As a postdoctoral scholar at Tufts University under Dr. Kaplan, my work shifted to developing full scale tissue models of the cornea. I was excited to join IVIVA following his passion for tissue engineering. As part of IVIVA’s engineering team, my work has been geared toward finding solutions to scale up our devices by increasing fluid channel packing density, improving scaffold architecture, and improving scaffold assembly techniques.
Nicole Diamantides, PhD, MS
I received my BS in Biomedical Engineering from Bucknell University and my MS and PhD in Biomedical Engineering from Cornell University. During my PhD, I worked on the development of novel collagen biomaterials for cartilage tissue engineering which exhibited rheological properties favorable for 3D bioprinting while maintaining the cell friendly characteristics of collagen hydrogels. At IVIVA, I’m working on optimizing our bulk material to find a solution which promotes desired cell behavior, can be incorporated into our manufacturing methods, and creates an overall robust device.
Natalie Condon, BS
I received my Bachelors of Science in Bioengineering from Lehigh University. During my time at Lehigh University, I worked on designing modular biomaterials for tissue engineering applications. Throughout the course of my undergraduate research, I became passionate about creating biomaterials-based scaffolds with tunable properties to aid in ending the global donor organ shortage. I was drawn to IVIVA Medical’s goal to fabricate scaffolds capable of replicating physiologically functional tissue constructs. I am excited for our team to develop perfusable tissue constructs that can be used in a variety of medical applications.
Pushpendra Yadav, MS, MS
I did my Integrated M.Sc. in Biology form UM-DAE CBS during my undergrad I developed an interest in Mechanobiology and Regenerative Medicine. As a result I pursued a Masters in Biomedical Engineering at Cornell University where I learned more about innovating and designing medical devices. I joined IVIVA to work on developing a functional tissue engineered kidney that can perform the ultrafiltration and reabsorption. I enjoy working on this complex system, where we have to mimic the microenvironment of cells, allow for crosstalk and maintain their functional phenotype.
Eduardo Enciso-Martínez, BS
I studied BSc in Biomedical Engineering at Tecnologico de Monterrey in Mexico. During my bachelors I completed an internship at Harvard Medical School in Prof. Su Ryon Shin tissue engineering laboratory. My research has been focused on the fields of biomaterials, 3D bioprinting, microfluidics and organ-on-a- chip. I joined IVIVA to support the biofabrication of physiologically relevant perfusable living tissues.
Evan Martin, BS
I received my BSc in Biological Engineering from Purdue University. During my undergraduate studies I completed several internships in the RNA research department at New England Biolabs. My research contributed to a project elucidating transcriptome variations across different tissues. Since graduating, I have worked to create in-vitro human tissue models and tissue therapeutics. I am inspired by IVIVA’s mission to engineer the next generation of functional human tissues.