WE BUILD ON A STRONG ACADEMIC FOUNDATION IN ORGAN ENGINEERING

All research and publications by
IVIVA Founder Harald Ott, MD

Organ Engineering is a multidisciplinary field that brings together stem cell and developmental biologists, engineers, physicians and surgeons to build living therapeutics with higher level function. We build on two decades of work providing peer reviewed proof of concept from small animal to human scale, from primary to allogeneic to hypoimmune cells and from simple structural components to advanced functions such as gas exchange, blood filtration, and reabsorption.

Research

Publications

2008
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Engineered rat heart and the dawn of the field of organ engineering

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Perfusion decellularized matrix: using nature’s platform for engineering bioartificial heart

Nature Medicine
2010
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Engineered and transplanted rat lung > gas exchange comparable to native lungs

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Regeneration and orthotopic transplantation of a bioartificial lung

Nature Medicine
2013
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Engineered and transplanted rat kidney

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Regeneration and orthotopic transplantation of a bioengineered kidney

Nature Medicine
2015
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Engineered
human
vasculature

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Engineering pulmonary vasculature in decellularized rat and human lungs

Nature Biotechnology
2016
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Engineered
human
myocardium

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Bioengineering human myocardium on native extracellular matrix

Circulation Research
2017
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Engineered and transplanted human intestinal grafts

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Bioengineering of functional human induced pluripotent stem cell-derived intestinal grafts

Nature Communications
2019
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Engineered and transplanted human pancreas

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Biofabrication of a vascularized islet organ for type 1 diabetes

Biomaterials
2021
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First transplantation of a bioengineered human scale organ

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Orthotopic transplantation of human bioartificial lung grafts in a porcine model

Seminar in Thoracic and Cardiovascular Surgery